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Pilot Study Shows Narrow Band Imaging with Colonoscopy Identifies Flast Dysplastic Lesions in Ulcerative Colitis Patients

Oak Brook, Ill. – November 19, 2007 – A pilot study from researchers at Kyushu University in Fukuoka, Japan, found that narrow band imaging (NBI) colonoscopy used in cancer surveillance for ulcerative colitis patients can identify flat dysplastic lesions. The research appears in the November issue of Gastrointestinal Endoscopy, the monthly peer-reviewed scientific journal of the American Society for Gastrointestinal Endoscopy.

Narrow band imaging (NBI) is a novel illumination technology for endoscopy characterized by light with wavelengths of narrow bands that improves the visibility of capillaries, veins and other subtle tissue structures by optimizing the absorbance and scattering characteristics of light. It enhances vasculature within and beneath the mucosa, or lining, of the gastrointestinal (GI) tract. Random biopsy has been a recommended procedure for cancer surveillance in patients with ulcerative colitis. Some studies have shown that chromoscopy, a dye spraying technique used with colonoscopy, with targeted biopsy identified dysplastic lesions (cell abnormalities that indicate progression to cancer) more frequently than did conventional colonoscopy in long-standing ulcerative colitis.

“Our pilot study indicated that the GI mucosal surface structure pattern classified as tortuous, discerned by NBI colonoscopy with a magnifying instrument, may be a clue for the identification of dysplasia in ulcerative colitis,” said study lead author Takayuki Matsumoto, MD, Kyushu University. “Because NBI colonoscopy is an easily applicable procedure without specific dye, it may be an alternative to magnifying chromoscopy for cancer surveillance in patients with ulcerative colitis. The value of the procedure for surveillance colonoscopy needs to be examined prospectively in a larger number of patients.”

Ulcerative colitis is a chronic (ongoing) disease of the colon, or large intestine. The disease is marked by inflammation and ulceration of the colon mucosa, or innermost lining. Because the inflammation makes the colon empty frequently, symptoms typically include diarrhea (sometimes bloody) and often crampy abdominal pain. According to the Crohn’s and Colitis Foundation of America, approximately half a million people in the United States have ulcerative colitis. Researchers do not know what causes the disease and there is no cure. The goal of treatment is to reduce the inflammatory response. Ulcerative colitis is a risk factor for developing colon cancer.

Patients and Methods
In this pilot study of 46 patients with ulcerative colitis, researchers applied NBI colonoscopy to cancer surveillance to investigate whether flat dysplastic lesions in ulcerative colitis could be identified by the procedure.

Patients, aged 18 to 67 years, who had left-sided colitis or pancolitis for more than seven years and who had clinically inactive disease were recruited for the study. Patients were examined by NBI colonoscopy. A magnifying colonoscope was connected to a prototype NBI system. Researchers first searched for sharply demarcated, protruding lesions under conventional colonoscopy and then changed the mode of observation to NBI colonoscopy.

Protruding lesions and flat mucosa were observed by NBI magnifying colonoscopy at a maximum of ×70 magnification. The flat areas of interest were identified by a brownish or discolored area distinct from the surrounding mucosa. Otherwise, indistinctive flat mucosa was assessed. The surface structure was classified into honeycomb-like, villous, or tortuous pattern. The honeycomb-like pattern was defined as a crowding of round capillary vessels in honeycomb appearances. The villous pattern was characterized by a cerebriform structure (like the brain in form). The tortuous pattern was defined as a pattern composed of round or ovoid structures of various sizes. The grade of dysplasia was determined in the biopsy specimens obtained from the protrusions and from the flat mucosa.

Results
A total of 296 sites (20 protruding lesions and 276 flat areas) were examined by NBI colonoscopy. The surface pattern was determined to be honeycomb like in 161 sites, villous in 85 sites, and tortuous in 50 sites. Five dysplastic lesions were detected in three patients. A patient had three dysplastic lesions and the other two had a dysplastic lesion each. The positive rate of dysplasia was higher in protrusions (2/20 sites, 10%) than in flat mucosa (3/276 sites, 1.1%, P = .038; however, correction for the multiple testing of data removes this significance). When the surface pattern was taken into account, the rate of positive dysplasia was higher in the tortuous pattern (4/50 sites, 8%) than in the honeycomb-like or villous patterns (1/246 sites, 0.4%, P = .003).

The tortuous pattern determined by NBI colonoscopy may be a clue for the identification of dysplasia during surveillance for ulcerative colitis.

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About the American Society for Gastrointestinal Endoscopy
Founded in 1941, the mission of the American Society for Gastrointestinal Endoscopy is to be the leader in advancing patient care and digestive health by promoting excellence in gastrointestinal endoscopy. ASGE, with more than 10,000 physician members worldwide, promotes the highest standards for endoscopic training and practice, fosters endoscopic research, recognizes distinguished contributions to endoscopy, and is the foremost resource for endoscopic education.

About Endoscopy
Endoscopy is performed by specially-trained physicians called endoscopists using the most current technology to diagnose and treat diseases of the gastrointestinal tract. Using flexible, thin tubes called endoscopes, endoscopists are able to access the human digestive tract without incisions via natural orifices. Endoscopes are designed with high-intensity lighting and fitted with precision devices that allow viewing and treatment of the gastrointestinal system. In many cases, screening or treatment of conditions can be delivered via the endoscope without the need for further sedation, treatment or hospital stay.