Rates of Metachronous Advanced Neoplasia After CRC Are Similar in Younger Versus Older People

Douglas K. Rex, MD, FASGE reviewing Tjaden J, et al. Clin Gastroenterol Hepatol 2019 July 24.

In 697 patients (92 were <50 years of age) followed after colorectal cancer (CRC) resection, the rate of advanced neoplasia at surveillance was similar in those <50 years (7.6%) versus those over 50 years (9.8%). In a multivariate analysis, predictors of advanced neoplasia at surveillance included synchronous advanced neoplasia at the time of the original CRC diagnosis, but not age.


Systematic testing of CRCs for Lynch features was not done in this study but is currently recommended for all CRCs. These data indicate that once Lynch is excluded based on tumor testing and genetic testing, when appropriate, patients <50 years can undergo postcancer resection surveillance colonoscopy at the same intervals used in older patients.

Note to readers:
At the time we reviewed this paper, its publisher noted that it was not in final form and that subsequent changes might be made.

Douglas K. Rex, MD, FASGE
Bio and Disclosures

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Tjaden J, Muller C, Wideroff G, et al. Metachronous advanced neoplasia on surveillance colonoscopy in young versus older onset colorectal cancer patients. Clin Gastroenterol Hepatol 2019 July 24. (Epub ahead of print) (https://doi.org/10.1016/j.cgh.2019.07.034)