reviewing Rutter MD, et al. Gut 2019 Nov 27.
Radical revisions have been made to British guidelines on postpolypectomy surveillance. Among the changes are new definitions for "high-risk group" and "premalignant" and a recommendation that patients without high-risk findings should return to routine fecal blood screening.
reviewing Archambault AN, et al. Gastroenterology 2019 Dec 19.
Everyone wants to understand the underlying drivers of the increase in early-onset colorectal cancer (CRC) and to have predictive risk scores that would allow tailored screening. In this case-control study involving multiple centers, 50,000 CRC cases, and 58,000 controls, a polygenic risk score based on 95 genetic variants was tested against CRC risk.
reviewing Niedermaier T, et al. Am J Gastroenterol 2019 Dec 10.
Fecal immunochemical test (FIT) sensitivity for colorectal cancer is often cited at about 80%, using the 20 microgram Hgb/g feces cut-off. However, it is important to know the stage-specific performance because detection of early stages has greater value than detection of late stages. This systematic review and meta-analysis of 44 studies examines the stage-specific sensitivity of FITs.
reviewing Faust N, et al. Gastroenterology 2019 Dec 6.
The National Health Interview Survey is conducted every 5 years and includes questions on genetic testing. In this study, responses from 2005, 2010, and 2015 regarding genetic testing discussion, recommendation, and completion were evaluated according to whether subjects had 0, 1, or ≥2 Lynch syndrome risk factors.