This study used the Utah Cancer Registry to examine cancer risk in patients with serrated polyposis syndrome (SPS) and their relatives as well as patients with sessile serrated lesions (SSLs) and their relatives. There were 59 patients with SPS, 754 patients with sporadic SSLs, and 1624 controls.
The risk of colorectal cancer (CRC) in the patients with SPS was increased (relative risk [RR], 10.68) with all of those cancers being diagnosed at the initial colonoscopy. First-degree relatives (FDRs) of patients with SPS had an RR of 5.54 for CRC. Tumors were proximal in 40% of patients with SPS and 33% of their FDRs. The FDRs of patients with SPS had a more than 2-fold increased risk of any-site cancer, but the finding was suspect because the relatives had an older mean age than the patients (70 vs 59 years) and the patients themselves did not have an increased risk of extracolonic cancers.
With regard to sporadic SSLs and the risk of CRC and extracolonic cancers in patients and their relatives, the results were inconclusive. One result indicated an increased risk of prostate cancer in patients with SSLs, and FDRs of these patients had increased CRC risk if the patient also had adenomas.
Kanth P, Yu Z, Keener MB, et al. Cancer risk in patients with and relatives of serrated polyposis syndrome and sporadic sessile serrated lesions. Am J Gastroenterol
2021 Dec 10. (Epub ahead of print) (https://doi.org/10.14309/ajg.0000000000001572