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Global Trends in Colorectal Cancer

Douglas K. Rex, MD, MASGE reviewing Morgan E, et al. Gut 2022 Sep 8.

Data on colorectal cancer (CRC) incidence and deaths were extracted from the GLOBOCAN database for 2020, and projections were made for 2040. Some of the key findings:

  • In 2020, there were 1.9 million new cases of CRC and 930,000 deaths.
  • By 2040, the burden is expected to increase to 3.2 million new cases and 1.6 million deaths.
  • There are 10-fold variations in incidence among 185 countries.
  • The highest incidence rates are in Europe and Australia/New Zealand, followed by Eastern Asia and North America. 
  • At a national level, the incidence rate in males was highest in Hungary at 62 per 100,000 and lowest in Mozambique at 3.6 per 100,000. 
  • For countries with a very high United Nations Human Development Index (HDI), the incidence rate in 2020 was 4 times higher than the rate in countries with a low HDI.


These data indicate that the incidence of CRC across the globe continues to be highly variable and most strongly associated with higher rates of human development.

Douglas K. Rex, MD, MASGE

Bio and Disclosures


Morgan E, Arnold M, Gini A, et al. Global burden of colorectal cancer in 2020 and 2040: incidence and mortality estimates from GLOBOCAN. Gut 2022 Sep 8. (Epub ahead of print) (